In this research area mechanisms are being explored which lead to the development of disease symptoms in severe allergy and asthma sufferers despite treatments that are in line with the latest scientific knowledge.
In 2010 new molecules that control the function of a specific cell were identified, which ultimately determine the onset and severity of an allergy. More precise characterisation of these molecules in future will lead to new curative therapies. It has also been shown that the abnormally high permeability of the epithelia in asthmatics is due to disruptions of cell-to-cell contacts. These are linked to inflammatory processes which lead to remodelling processes in the underlying connective tissue.
The results achieved have been presented to the scientific community at national and international conferences and published in nine publications in prominent journals.